Vaginal fluid simulant

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Pharmaceutical Research. The safe and functional delivery of progesterone through the vaginal route remains an unmet clinical need. The purpose of this work is to prepare a new progesterone P4 gel for vaginal application using a thermosensitive mucoadhesive polymer, glycol chitin GC. Thermogelling, mucoadhesive, mechanical, and viscoelastic properties of GC and the new formulation were evaluated using rheometry.

Skip to search form Skip to main content. A vaginal fluid simulant. The composition of the medium was based on an extensive review of the literature on constituents of human vaginal secretions.

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The aim of our study was to develop a liposomal carrier system for the local treatment of bacterial vaginosis, capable to efficiently deliver entrapped drug during an extended period of time. Both liposome preparations were characterised and compared for particle size, polydispersity, entrapment efficiency and tested for in vitro stability in media that simulate human vaginal conditions buffer pH 4. To achieve application viscosity of liposomes and to further improve their stability, liposomes prepared by the proliposome method were incorporated in the bioadhesive gel made of Carbopol P NF resin.

Scientific Research An Academic Publisher. Owen, D. Contraception, 59,

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E-mail address: arg4 duke. Use the link below to share a full-text version of this article with your friends and colleagues. Learn more. An effective vaginal microbicide formulation must distribute and maintain an epithelial coating layer.

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English Turkish English Login. Marmara Pharmaceutical Journal. YearVolume 21, Issue 4, Pages - Zotero Mendeley EndNote.

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